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About Colchicine
Uses of Colchicine-Probenecid
Colchicine Probenecid is a combination of colchicine and probenecid. Colchicine
is used in the treatment of gout. It relieves the pain of gout and
helps prevent further attacks. Probenecid helps clear the body of
uric acid which is increased in cases of gout. The combination is
effective in the treatment of gout.
How to Use Colchicine-Probenecid
Colchicine Probenecid is taken after an acute attack of gout has
ended. It will not relieve an attack in progress. While taking this
medication, drink at least six to eight 8 oz glasses of fluid a
day to help prevent development of kidney stones. To help relieve
stomach upset, colchicine probenecid may be taken with food or antacids.
Side Effects of Colchicine-Probenecid
Stomach pain, loss of appetite, nausea, or vomiting may occur as
your body adjusts to colchicine probenecid. Inform your doctor if
these effects persist or become bothersome. Notify your doctor if
you develop: yellowing of the eyes or skin, sore throat, easy bruising
or bleeding, muscle aches, numbness or tingling of legs and arms,
fatigue, rash, fever, sore gums, breathing difficulties, itchy skin.
If you notice other effects not listed above, contact your doctor
or pharmacist.
Precautions with Colchicine-Probenecid
Alcohol can decrease the effectiveness of this medication. Limit
alcohol consumption while taking this. Before having surgery, including
dental surgery, tell your doctor you are taking colchicine with
probenecid. If you have kidney, stomach, intestinal, heart or bleeding
disorder problems, tell your doctor before you take this drug. The
colchicine in this combination product is not recommended for use
during pregnancy. Consult your doctor before using this medication.
Colchicine passes into breast milk, though the effects on a nursing
infant are in question. Consult your doctor before you breast-feed.
Colchicine-Probenecid Drug Interactions
Inform your doctor about all the medicines you use (both prescription
and nonprescription), especially of: methotrexate, penicillin-like
antibiotics, cephalosporins (e.g., cephalexin), oral diabetes medicines,
indomethacin, nitrofurantoin. Aspirin and salicylate-type medicines
can prevent probenecid from being fully effective. It is best to
avoid these products. If you are to take a urine test while using
this medication, tell the doctor or laboratory personnel that you
are taking colchicine because colchicine may affect the test results.
Do not start or stop any medicine without doctor or pharmacist approval.
Colchicine-Probenecid Overdose
If overdose is suspected, contact your local poison control center
or emergency room immediately. Symptoms of overdose may include
nausea; vomiting; diarrhea; stomach pain; burning pain in throat,
stomach, and skin; blood in urine; and muscle weakness.
Notes
Colchicine Probenecid relieves pain but only pain associated with
gout. It should not be used for any other type of pain. Do not allow
anyone else to take this medication.
Colchicine-Probenecid Missed Dose
If you miss a dose of colchicine probenecid, take as soon as remembered;
do not take if it is almost time for the next dose, instead, skip
the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.
Storage
Store colchicine probenecid at room temperature away from sunlight
and moisture.
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